Collaboration Leads to Understanding of Apoptosis in Colon Cancer

Collaborating with the UNC Greensboro Center for Translational Biomedical Research at the NC Research Campus (NCRC) in Kannapolis, the In Vitro Sciences (IVTS) Laboratory designed flow cytometry studies to demonstrate how Asymmetric dimethylarginine (ADMA) reduces cancer cell apoptosis. 

In the IVTS laboratory, scientists worked with UNC Greensboro to design the study including drug conditions, doses, timing and other details of the treatment of the cancer cells. Lab scientists examined cell death in colon cancer cells using Annexin V and Propidium Iodide on a Flow Cytometry Analyzer. 

“Applying the depth of our knowledge in Flow Cytometry helped our colleague advance his research on colon cancer by allowing him to see the effectiveness of this particular pathway for apoptosis and to better understand the mechanism of action of this compound,” said Qi Jiang, MD, PhD, IVTS group leader.

The results were published in the journal Cell Death and Disease in the paper “Asymmetric dimethylarginine attenuates serum starvation‐induced apoptosis via suppression of the Fas (APO‐1/CD95)/JNK (SAPK) pathway.”

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