Duke Cancer Institute, the MURDOCK Study and the David H. Murdock Research Institute (DHMRI) are collaborating on prostate cancer research in hopes of better understanding why African American men frequently have a more aggressive form of the disease. The MURDOCK Study will provide samples from more than 600 MURDOCK Study participants for the project, "Population-level interrogation of novel alternatively spliced genes in race-related aggressive prostate cancer.” Targeted DNA and RNA sequencing experiments are planned with the Genomics Laboratory at the DHMRI, representing another partnership between the NC Research Campus and university collaborators like Duke.
African American men exhibit two-fold higher incidence and three-fold higher mortality rates from prostate cancer, compared with white men. In North Carolina, African American men are nearly 20 percent more likely to die from prostate cancer than their white counterparts. Much of this disparity remains after controlling for factors related to access to care. Previous work from the laboratory of Steven R. Patierno, PhD, deputy director for the Duke Cancer Institute, in collaboration with the Lee laboratory at George Washington University, has used this difference between African American and white men to better understand tumor aggressiveness at the molecular level, as well as biomarkers and molecular targets that could help lead to new approaches for prevention and treatment. Patierno is principal investigator for the MURDOCK Prostate Cancer project.
The MURDOCK Study has identified more than 200 reported prostate cancer cases and will also provide healthy samples for controls. This study has the potential to pave the way toward developing targeted approaches for prevention and treatment of the disease that could help reduce prostate cancer disparities for African Americans and improve outcomes for men of all races with aggressive disease.
Lead Sub Investigator is Jennifer A. Freeman, PhD, Assistant Professor of Medicine and Chief Scientist of the Genitourinary Oncology Research Program, DCI and Duke University Medical Center.
Lead Postdoctoral Researcher is April Deveaux, MD, PhD, Postdoctoral Associate, Genitourinary Oncology Laboratory, Department of Medicine, DCI and Duke University Medical Center.
MURDOCK Study Project Lead is Douglas Wixted, MMCi, project leader for Strategy, Infrastructure & Informatics for Duke Translational Research Institute (DTRI) Population Health Research.
Learn more here.