The Analytical Sciences team possesses a broad base of scientific and analytical experience that allows them to apply metabolomics, proteomics or nuclear magnetic spectroscopy (NMR) across a broad range of scientific studies.
Kevin Knagge, PhD
Analytical Sciences Group Leader,
NMR Project Leader
Kevin Knagge, PhD, oversees the Analytical Sciences Laboratory and collaborates with scientists to analyze and quantify a variety of compounds for chemical and biochemical applications. His work involves identifying and quantifying bioactive and structurally important compounds (including metabolites) in plants and animals, protein/molecular interactions, and protein structure determination. He is co-author of many published research articles. He previously worked for Bruker Biospin and as a postdoctoral researcher at the University of Iowa. He holds a doctorate in analytical chemistry from Purdue University and a bachelor’s of science in chemical engineering from the University of Illinois at Urbana-Champaign.
Jason Winnike, PhD
Jason Winnike, PhD, provides scientific expertise in metabolomics and small molecule analysis. He specializes in multivariate statistics, stable isotope tracing and analytical tools such as NMR and mass spectrometry. Before DHMRI, he worked as a postdoctoral associate in the department of Chemistry at the University of Louisville and as a laboratory manager at the Metabolomics Facility at the University of North Carolina at Chapel Hill (UNCCH). He earned doctorate and master’s degrees in biomedical engineering from the joint Department of Biomedical Engineering at UNCCH and North Carolina State University. Throughout his career, he has co-authored numerous journal articles.
Huadong Chen, PhD
Huadong Chen is skilled in pharmacokinetic modeling and drug metabolism with extensive experience using GC-MS, LC-MS and NMR for metabolomic studies. His skills extend to sample preparation, extraction, fractionation, enrichment, chemical derivatization, biotransformation and bioavailability of drugs. He is a well-published author whose previous experience includes a post-doctoral fellowship with the NC A&T State University Center for Excellence in Post-Harvest Technologies at the NC Research Campus. He holds a doctorate degree in medicinal chemistry from the State Key Laboratory of Drug Research and worked in the BioEnergy Genome Center, both part of the Chinese Academy of Sciences.
Huiyuan Chen, MS
Huiyuan Chen performs global metabolite profiling of biological samples and is responsible for building the DHMRI’s in-house MS/MS library to ensure accurate compound identification. He develops methods for quantification of various compounds in a variety of matrixes with LC-MS and GC-MS. He has several published research articles and has experience in untargeted metabolomics, small molecule analysis, mass spectrometry, chromatographic separation techniques, extraction and quantitation of small-molecule metabolites in different biological samples. He holds a master’s degree in nutrition from the University of North Carolina at Greensboro.
David Kirchner, MS
David Kirchner, MS, manages the proteomics laboratory where he combines protein sample preparation with mass spectrometry analysis, high-throughput robotics and integrated data management systems to provide automated and streamlined solutions for protein biomarker analysis and identification from purified samples or complex protein mixtures. His expertise extends to bioinformatics and metabolomics. He worked previously as an analytical biochemist at Windber Research Institute in Pennsylvania, a laboratory manager and instructor at Frostburg State University in Maryland and a senior molecular biology research technician and instructor at Alleghany College of Maryland.
Kyle Blankenship is responsible for preparing and running samples on GC-MS, liquid chromatography MS and NMR instrumentation. He also serves as the safety officer for the proteomics and metabolomics laboratories and assists with inventory, ordering and equipment maintenance. After holding jobs in manufacturing and logistics, Kyle graduated from Rowan-Cabarrus Community College with an associate of applied science degree in biotechnology. He interned in the Appalachian State University Human Performance Laboratory on the NC Research Campus before joining DHMRI.
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